abstract：:Archaeologically defined Upper Palaeolithic (UP, 45,000-10,000 years ago) "cultures" are often used as proxies to designate fossil populations. While recent genomic studies have partly clarified the complex relationship between European UP "cultures" and past population dynamics, they leave open numerous questions reg...

journal_title：Scientific reports

authors： Mounier A,Heuzé Y,Samsel M,Vasilyev S,Klaric L,Villotte S

更新日期：2020-12-14 00:00:00

abstract：:We propose a novel class of mixed fluctuations with different orientations and fractal scaling features as a model for anisotropic two-dimensional (2D) trajectories hypothesized to appear in complex systems. Furthermore, we develop the oriented fractal scaling component analysis (OFSCA) to decompose such mixed fluctua...

journal_title：Scientific reports

authors： Seleznov I,Popov A,Kikuchi K,Kolosova E,Kolomiiets B,Nakata A,Kaneko M,Kiyono K

更新日期：2020-12-14 00:00:00

abstract：:The aim of this study was to identify novel plasma metabolic signatures with possible relevance during multiple myeloma (MM) development and progression. A biochemical quantitative phenotyping platform based on targeted electrospray ionization tandem mass spectrometry technology was used to aid in the identification o...

journal_title：Scientific reports

authors： da Silva IDCG,de Castro Levatti EV,Pedroso AP,Marchioni DML,Carioca AAF,Colleoni GWB

更新日期：2020-12-14 00:00:00

abstract：:Ancient statues are usually fragile and have a tendency to deteriorate over time, developing cracks, corrosion, and losing color. Before any intervention on the object of art, a conservator must map degradation and take measurements. Deterioration mapping is an extremely long process, as the conservator or restorer mu...

journal_title：Scientific reports

authors： Nasri A,Huang X

更新日期：2020-12-14 00:00:00

abstract：:Increasing evidence suggest that the glucose-lowering drug metformin exerts a valuable anti-senescence role. The ability of metformin to affect the biogenesis of selected microRNAs (miRNAs) was recently suggested. MicroRNA isoforms (isomiRs) are distinct variations of miRNA sequences, harboring addition or deletion of...

journal_title：Scientific reports

authors： Giuliani A,Londin E,Ferracin M,Mensà E,Prattichizzo F,Ramini D,Marcheselli F,Recchioni R,Rippo MR,Bonafè M,Rigoutsos I,Olivieri F,Sabbatinelli J

更新日期：2020-12-11 00:00:00

abstract：:Soybean is an important source of protein, oil and carbohydrates, as well as other beneficial nutrients. A major function of proteins in nutrition is to supply adequate amounts of amino acids. Although they are essential for human nutrition, the sulfur-containing amino acids cysteine (Cys) and methionine (Met) are oft...

journal_title：Scientific reports

authors： Malle S,Eskandari M,Morrison M,Belzile F

更新日期：2020-12-11 00:00:00

abstract：:Sterile liver inflammation and fibrosis are associated with many liver disorders of different etiologies. Both type 1 and type 2 inflammatory responses have been reported to contribute to liver pathology. However, the mechanisms controlling the balance between these responses are largely unknown. Natural killer T (NKT...

journal_title：Scientific reports

authors： Nilsson J,Hörnberg M,Schmidt-Christensen A,Linde K,Nilsson M,Carlus M,Erttmann SF,Mayans S,Holmberg D

更新日期：2020-12-11 00:00:00

abstract：:Tuberculosis is the leading cause of death among people living with HIV (PLH). Preventive tuberculosis therapy reduces mortality in PLH, especially in those with a positive tuberculin skin test (TST). New, more specific technologies for detecting latent tuberculosis infection (LTBI) are now commercially available. We ...

journal_title：Scientific reports

authors： Steffen RE,Pinto M,Kritski A,Trajman A

更新日期：2020-12-11 00:00:00

abstract：:William Adams (Miura Anjin) was an English navigator who sailed with a Dutch trading fleet to the far East and landed in Japan in 1600. He became a vassal under the Shogun, Tokugawa Ieyasu, was bestowed with a title, lands and swords, and became the first SAMURAI from England. "Miura" comes from the name of the territ...

journal_title：Scientific reports

authors： Mizuno F,Ishiya K,Matsushita M,Matsushita T,Hampson K,Hayashi M,Tokanai F,Kurosaki K,Ueda S

更新日期：2020-12-10 00:00:00

abstract：:Volatile organic compounds (VOCs) represent a broad class of chemicals, many of which can be found in indoor air including residential indoor air. VOCs derive from a variety of sources including cleaning products, cooking practices, fragrances and fresheners, hobbies and at-home work behaviors. This study examined res...

journal_title：Scientific reports

authors： Wickliffe JK,Stock TH,Howard JL,Frahm E,Simon-Friedt BR,Montgomery K,Wilson MJ,Lichtveld MY,Harville E

更新日期：2020-12-10 00:00:00

abstract：:The COVID-19 pandemic has exceeded over sixty-five million cases globally. Different approaches are followed to mitigate its impact and reduce its spreading in different countries, but limiting mobility and exposure have been de-facto precautions to reduce transmission. However, a full lockdown cannot be sustained for...

journal_title：Scientific reports

authors： Parajuli RR,Mishra B,Banstola A,Ghimire BR,Poudel S,Sharma K,Dixit SM,Sah SK,Simkhada P,van Teijlingen E

更新日期：2020-12-10 00:00:00

abstract：:The relative and combined effects of sleep apnea with diabetes mellitus (DM) on cardiovascular outcomes in patients undergoing coronary artery bypass grafting (CABG) remain unknown. In this secondary analysis of data from the SABOT study, 1007 patients were reclassified into four groups based on their sleep apnea and ...

journal_title：Scientific reports

authors： Aung AT,Koo CY,Tam WW,Chen Z,Kristanto W,Sim HW,Kojodjojo P,Kofidis T,Lee CH

更新日期：2020-12-10 00:00:00

abstract：:Ras mutations (e.g., occur in K-Ras, N-Ras, and H-Ras) are one of the most desirable and promising drug targets in chemotherapy treatments for cancer. However, there are still no approved drugs directly targeting mutated Ras. In 2017, an artificial cyclic peptide, KRpep-2d, was discovered as the first selective inhibi...

journal_title：Scientific reports

authors： Sakamoto K,Masutani T,Hirokawa T

更新日期：2020-12-10 00:00:00

abstract：:Cell-free DNA is present in different biological fluids and when released by tumor cells may contribute to pro-tumor events such as malignant transformation of cells adjacent to the tumor and metastasis. Thus, this study analyzed the effect of tumor cell-free DNA, isolated from the blood of prostate cancer patients, o...

journal_title：Scientific reports

authors： Souza AG,Bastos VAF,Fujimura PT,Ferreira ICC,Leal LF,da Silva LS,Laus AC,Reis RM,Martins MM,Santos PS,Corrêa NCR,Marangoni K,Thomé CH,Colli LM,Goulart LR,Goulart VA

更新日期：2020-12-10 00:00:00

abstract：:We investigated the relationship between aqueous cytokine levels, changes in ocular blood flow, and morphological and functional improvements after intravitreal ranibizumab injection (IRI) in treatment-naïve eyes with center-involving diabetic macular edema (DME). Thirty-three eligible patients with DME (33 eyes) were...

journal_title：Scientific reports

authors： Mizui T,Noma H,Yasuda K,Kanemaki T,Goto H,Shimura M

更新日期：2020-12-10 00:00:00

abstract：:It is generally believed that anthropogenic aerosols cool the atmosphere; therefore, they offset the global warming resulting from greenhouse gases to some extent. Reduction in sulphate, a primary anthropogenic aerosol, is necessary for mitigating air pollution, which causes atmospheric warming. Here, the changes in t...

journal_title：Scientific reports

authors： Takemura T

更新日期：2020-12-10 00:00:00

abstract：:In glaucoma, retinal ganglion cells degenerate progressively, leading to visual field loss and blindness. Presently, the only treatment strategy for glaucoma is lowering the intraocular pressure. However, there are cases in which patients develop progressive visual field loss even though their intraocular pressures ar...

journal_title：Scientific reports

authors： Hasegawa T,Ikeda HO,Iwai S,Sasaoka N,Kakizuka A,Tsujikawa A

更新日期：2020-12-10 00:00:00

abstract：:Learning to successfully navigate social environments is a critical developmental goal, predictive of long-term wellbeing. However, little is known about how people learn to adjust to different social environments, and how this behaviour emerges across development. Here, we use a series of economic games to assess how...

journal_title：Scientific reports

authors： Westhoff B,Molleman L,Viding E,van den Bos W,van Duijvenvoorde ACK

更新日期：2020-12-10 00:00:00

abstract：:Invasive non-native species have pervasive impacts on native biodiversity, including population extirpations and species extinctions. Identifying reasons why a population of a native species is extirpated following an invasion often relies on literature-based results of anecdotal observations. The well-established sch...

journal_title：Scientific reports

authors： Haubrock PJ,Balzani P,Britton JR,Haase P

更新日期：2020-12-10 00:00:00

abstract：:The AMP-activated kinase (AMPK) is a major energy sensor metabolic enzyme that is activated early during T cell immune responses but its role in the generation of effector T cells is still controversial. Using both in vitro and in vivo models of T cell proliferation, we show herein that AMPK is dispensable for early T...

journal_title：Scientific reports

authors： Lepez A,Pirnay T,Denanglaire S,Perez-Morga D,Vermeersch M,Leo O,Andris F

更新日期：2020-12-10 00:00:00

abstract：:Erwinia tracheiphila is a bacterial plant pathogen that causes a fatal wilt infection in some cucurbit crop plants. Wilt symptoms are thought to be caused by systemic bacterial colonization through xylem that impedes sap flow. However, the genetic determinants of within-plant movement are unknown for this pathogen spe...

journal_title：Scientific reports

authors： Rocha J,Shapiro LR,Kolter R

更新日期：2020-12-10 00:00:00

abstract：:We have measured artificial radionuclides, such as 90Sr and 137Cs, in atmospheric depositions since 1957 in Japan. We observed the variations in 90Sr and 137Cs, which were emitted from atmospheric nuclear tests and nuclear power plant accidents, due to their diffusion, deposition, and resuspension. In March 2011, the ...

journal_title：Scientific reports

authors： Kinase T,Adachi K,Sekiyama TT,Kajino M,Zaizen Y,Igarashi Y

更新日期：2020-12-10 00:00:00

abstract：:Human children show unique cognitive skills for dealing with the social world but their cognitive performance is paralleled by great apes in many tasks dealing with the physical world. Recent studies suggested that members of a songbird family-corvids-also evolved complex cognitive skills but a detailed understanding ...

journal_title：Scientific reports

authors： Pika S,Sima MJ,Blum CR,Herrmann E,Mundry R

更新日期：2020-12-10 00:00:00

abstract：:Cell counts decrease with sediment depth. Typical explanations consider limiting factors such as water availability and chemistry, carbon source, nutrients, energy and temperature, and overlook the role of pore size. Our analyses consider sediment self-compaction, the evolution of pore size with depth, and the probabi...

journal_title：Scientific reports

authors： Park J,Santamarina JC

更新日期：2020-12-10 00:00:00

abstract：:Visual reasoning is critical in many complex visual tasks in medicine such as radiology or pathology. It is challenging to explicitly explain reasoning processes due to the dynamic nature of real-time human cognition. A deeper understanding of such reasoning processes is necessary for improving diagnostic accuracy and...

journal_title：Scientific reports

authors： Li Y,Cao H,Allen CM,Wang X,Erdelez S,Shyu CR

更新日期：2020-12-10 00:00:00

abstract：:The expression of aminoglycoside-modifying enzymes represents a survival strategy of antibiotic-resistant bacteria. Aminoglycoside 2'-N-acetyltransferase [AAC(2')] neutralizes aminoglycoside drugs by acetylation of their 2' amino groups in an acetyl coenzyme A (CoA)-dependent manner. To understand the structural featu...

journal_title：Scientific reports

authors： Jeong CS,Hwang J,Do H,Cha SS,Oh TJ,Kim HJ,Park HH,Lee JH

更新日期：2020-12-09 00:00:00

abstract：:Histone lysine methyltransferases (KMTs) play an important role in epigenetic gene regulation and have emerged as promising targets for drug discovery. However, the scope and limitation of KMT catalysis on substrates possessing substituted lysine side chains remain insufficiently explored. Here, we identify new unnatu...

journal_title：Scientific reports

authors： Al Temimi AHK,Merx J,van Noortwijk CJ,Proietti G,Buijs R,White PB,Rutjes FPJT,Boltje TJ,Mecinović J

更新日期：2020-12-09 00:00:00

abstract：:We aimed to predict molecular subtypes of breast cancer using radiomics signatures extracted from synthetic mammography reconstructed from digital breast tomosynthesis (DBT). A total of 365 patients with invasive breast cancer with three different molecular subtypes (luminal A + B, luminal; HER2-positive, HER2; triple...

journal_title：Scientific reports

authors： Son J,Lee SE,Kim EK,Kim S

更新日期：2020-12-09 00:00:00

abstract：:Survivors of childhood acute lymphoblastic leukemia (cALL) are at higher risk of developing cardiometabolic complications. We aimed at exploring the associations between biomarkers of inflammation, oxidative stress, endothelial function, endotoxemia and cardiometabolic risk factors. We conducted a cross-sectional anal...

journal_title：Scientific reports

authors： Morel S,Léveillé P,Samoilenko M,Franco A,England J,Malaquin N,Tu V,Cardin GB,Drouin S,Rodier F,Lippé S,Krajinovic M,Laverdière C,Sinnett D,Lefebvre G,Levy E,Marcil V

更新日期：2020-12-09 00:00:00

abstract：:Rhizomorphic lycopsids are the land plant group that includes the first giant trees to grow on Earth and extant species in the genus Isoetes. Two mutually exclusive hypotheses account for the evolution of terminal rooting axes called rootlets among the rhizomorphic lycopsids. One hypothesis states that rootlets are tr...

journal_title：Scientific reports

authors： Hetherington AJ,Emms DM,Kelly S,Dolan L

更新日期：2020-12-09 00:00:00

abstract：:Dopamine is an important neurotransmitter that plays a key role in a wide range of both locomotive and cognitive functions in humans. Disturbances on the dopaminergic system cause, among others, psychosis, Parkinson's disease and Huntington's disease. Antipsychotics are drugs that interact primarily with the dopamine ...

journal_title：Scientific reports

authors： Goode-Romero G,Winnberg U,Domínguez L,Ibarra IA,Vargas R,Winnberg E,Martínez A

更新日期：2020-12-09 00:00:00

abstract：:We investigated the cognitive and behavioral profile of three distinct groups of epilepsies with a genetic background for intergroup differences: (1) idiopathic/genetic generalized epilepsies (IGE/GGE group); (2) idiopathic focal epilepsies (IFE group); and (3) epilepsies with proven or strongly suggested monogenic or...

journal_title：Scientific reports

authors： Moorhouse FJ,Cornell S,Gerstl L,Tacke M,Roser T,Heinen F,Bonfert M,von Stülpnagel C,Wagner M,Borggraefe I

更新日期：2020-12-09 00:00:00

abstract：:The use of nanocarriers composed of polyethylene glycol- and polyvinyl alcohol-coated vesicles encapsulating active molecules in place of conventional chemotherapy drugs can reduce many of the chemotherapy-associated challenges because of the increased drug concentration at the diseased area in the body. The present s...

journal_title：Scientific reports

authors： Ebadi M,Bullo S,Buskara K,Hussein MZ,Fakurazi S,Pastorin G

更新日期：2020-12-09 00:00:00

abstract：:The commensal microbiome is known to influence a variety of host phenotypes. Microbiome profiling followed by differential abundance analysis has been established as an effective approach to study the mechanisms of host-microbiome interactions. However, it is challenging to interpret the collective functions of the re...

journal_title：Scientific reports

authors： Kou Y,Xu X,Zhu Z,Dai L,Tan Y

更新日期：2020-12-08 00:00:00

abstract：:Prior ex vivo histological postmortem studies of autism spectrum disorder (ASD) have shown gray matter microstructural abnormalities, however, in vivo examination of gray matter microstructure in ASD has remained scarce due to the relative lack of non-invasive methods to assess it. The aim of this work was to evaluate...

journal_title：Scientific reports

authors： McKenna F,Miles L,Donaldson J,Castellanos FX,Lazar M

更新日期：2020-12-08 00:00:00

abstract：:Stroke is a leading cause of death and the leading cause of long-term disability, but its electrophysiological basis is poorly understood. Characterizing acute ischemic neuronal activity dynamics is important for understanding the temporal and spatial development of ischemic pathophysiology and determining neuronal ac...

journal_title：Scientific reports

authors： Wann EG,Wodeyar A,Srinivasan R,Frostig RD

更新日期：2020-12-08 00:00:00

abstract：:Since the introduction of leukemia-type induction therapies for T-cell lymphoblastic lymphoma (T-LBL), improvements in the long-term outcomes of T-LBL have been reported. However, indications for and the appropriate timing of hematopoietic stem cell transplantation (HSCT) have not yet been established. Therefore, we p...

journal_title：Scientific reports

authors： Morita-Fujita M,Arai Y,Yoshioka S,Ishikawa T,Kanda J,Kondo T,Akasaka T,Ueda Y,Imada K,Moriguchi T,Yago K,Kitano T,Yonezawa A,Nohgawa M,Takaori-Kondo A,Kyoto Stem Cell Transplantation Group (KSCTG).

更新日期：2020-12-08 00:00:00

abstract：:Current image processing methods for dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) do not capture complex dynamic information of time-signal intensity curves. We investigated whether an autoencoder-based pattern analysis of DSC MRI captured representative temporal features that improves tissue...

journal_title：Scientific reports

authors： Park JE,Kim HS,Lee J,Cheong EN,Shin I,Ahn SS,Shim WH

更新日期：2020-12-08 00:00:00

abstract：:Clinical success of effective gene therapy is mainly hampered by the insufficiency of safe and efficient internalization of a transgene to the targeted cellular site. Therefore, the development of a safe and efficient nanocarrier system is one of the fundamental challenges to transfer the therapeutic genes to the dise...

journal_title：Scientific reports

authors： Tariq I,Ali MY,Sohail MF,Amin MU,Ali S,Bukhari NI,Raza A,Pinnapireddy SR,Schäfer J,Bakowsky U

更新日期：2020-12-08 00:00:00

abstract：:Obstacles to widespread deployments of direct air capture of CO2 (DAC) lie in high material and energy costs. By grafting quaternary ammonium (QA) functional group to mesoporous polymers with high surface area, a unique DAC adsorbent with moisture swing adsorption (MSA) ability and ultra-high kinetics was developed in...

journal_title：Scientific reports

authors： Wang T,Wang X,Hou C,Liu J

更新日期：2020-12-08 00:00:00